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587 results

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Page 1
Development and Validation of a Discriminatory Dissolution Method for Rifaximin Products.
Dharani S, Barakh Ali SF, Afrooz H, Khan MA, Rahman Z. Dharani S, et al. J Pharm Sci. 2019 Jun;108(6):2112-2118. doi: 10.1016/j.xphs.2019.01.020. Epub 2019 Jan 24. J Pharm Sci. 2019. PMID: 30685397
The objective of this study was to develop a discriminatory dissolution method that can detect low levels of alpha to beta transformation in RFX products. ...Dissolution in water with 0.2% sodium lauryl sulfate was less than 80% and nondiscriminatory. ...
The objective of this study was to develop a discriminatory dissolution method that can detect low levels of alpha to beta tra …
Development and Validation of a Discriminative Dissolution Medium for a Poorly Soluble Nutraceutical Tetrahydrocurcumin.
Shiek Abdul Kadhar Mohamed Ebrahim HR, Chungath TT, Sridhar K, Siram K, Elumalai M, Ranganathan H, Muthusamy S. Shiek Abdul Kadhar Mohamed Ebrahim HR, et al. Turk J Pharm Sci. 2021 Oct 28;18(5):565-573. doi: 10.4274/tjps.galenos.2021.91145. Turk J Pharm Sci. 2021. PMID: 34719154 Free PMC article.
OBJECTIVES: The present study aimed to develop and validate a discriminative dissolution method for tetrahydrocurcumin (THC), a Biopharmaceutical Classification System class II drug, by a simple ultraviolet (UV) spectrophotometric analysis. ...The validati …
OBJECTIVES: The present study aimed to develop and validate a discriminative dissolution method for tetrahydrocurcumin …
Development and Validation of Discriminative Dissolution Method for Metformin Immediate-Release Film-Coated Tablets.
Mitrevska I, Achkoska T, Brezovska K, Toshev K, Dimitrovska A, Ugarkovic S. Mitrevska I, et al. J Anal Methods Chem. 2019 Dec 10;2019:4296321. doi: 10.1155/2019/4296321. eCollection 2019. J Anal Methods Chem. 2019. PMID: 31886020 Free PMC article.
The purpose of this study was to develop and validate a discriminative dissolution method for the metformin film-coated tablet with immediate release of the active substance that belongs to class III of the Biopharmaceutical Classification System (BCS). ...A …
The purpose of this study was to develop and validate a discriminative dissolution method for the metformin film-coated …
Development, validation and application of physiologically based biopharmaceutics model to justify the change in dissolution specifications for DRL ABC extended release tablets.
Jaiswal S, Ahmed T, Kollipara S, Bhargava M, Chachad S. Jaiswal S, et al. Drug Dev Ind Pharm. 2021 May;47(5):778-789. doi: 10.1080/03639045.2021.1934870. Epub 2021 Jun 8. Drug Dev Ind Pharm. 2021. PMID: 34082622
METHODS: PBBM was developed for DRL ABC using literature reported pharmacokinetic (PK) data. The intravenous PK data and in vitro metabolic rate constants were utilized for developing PBPK model first, followed by that in conjugation with mechanistic ACAT(TM) …
METHODS: PBBM was developed for DRL ABC using literature reported pharmacokinetic (PK) data. The intravenous PK data and in vi …
Development and validation of a model for the early prediction of the RRT requirement in patients with rhabdomyolysis.
Liu C, Yuan Q, Mao Z, Hu P, Wu R, Liu X, Hong Q, Chi K, Geng X, Sun X. Liu C, et al. Am J Emerg Med. 2021 Aug;46:38-44. doi: 10.1016/j.ajem.2021.03.006. Epub 2021 Mar 8. Am J Emerg Med. 2021. PMID: 33714053
The data collected from the Chinese PLAGH were used for external validation. The factors predictive of the need for RRT were selected using a LASSO regression analysis. ...The AUC of the model in the training dataset was 0.818 (95% CI 0.78-0.87), the AUC in the test datase …
The data collected from the Chinese PLAGH were used for external validation. The factors predictive of the need for RRT were selected …
Development and Characterization of Venetoclax Nanocrystals for Oral Bioavailability Enhancement.
Kala SG, Chinni S. Kala SG, et al. AAPS PharmSciTech. 2021 Mar 8;22(3):92. doi: 10.1208/s12249-021-01968-1. AAPS PharmSciTech. 2021. PMID: 33683477
Process parameters like concentration of stabilizer, homogenization pressure, number of homogenization cycle, and concentration of lyoprotectant were optimized to obtain the desired particle size for the preparation of nanocrystal formulation. HPLC methods were develope …
Process parameters like concentration of stabilizer, homogenization pressure, number of homogenization cycle, and concentration of lyoprotec …
Design, Development, Optimization and Evaluation of Ranolazine Extended Release Tablets.
Gunda RK, Manchineni PR, Duraiswamy D, Gsn KR. Gunda RK, et al. Turk J Pharm Sci. 2022 Apr 29;19(2):125-131. doi: 10.4274/tjps.galenos.2021.58047. Turk J Pharm Sci. 2022. PMID: 35509223 Free PMC article.
The amount of polymers with desired sustained drug release was labeled as factors. On other hand, time taken for drug dissolution was labeled as responses (t(10%), t(50%), t(75%), t(90%)). ...Data obtained from the dissolution study fitted well to kinetic modeling a …
The amount of polymers with desired sustained drug release was labeled as factors. On other hand, time taken for drug dissolution was …
An overview of experimental designs in HPLC method development and validation.
Sahu PK, Ramisetti NR, Cecchi T, Swain S, Patro CS, Panda J. Sahu PK, et al. J Pharm Biomed Anal. 2018 Jan 5;147:590-611. doi: 10.1016/j.jpba.2017.05.006. Epub 2017 May 7. J Pharm Biomed Anal. 2018. PMID: 28579052 Review.
The present manuscript discusses usefulness of various chemometric approaches in high and ultra performance liquid chromatography for (i) methods development from dissolution studies and sample preparation to detection, considering the progressive substitutio …
The present manuscript discusses usefulness of various chemometric approaches in high and ultra performance liquid chromatography for (i) …
Pinaverium Bromide: Development and Validation of Spectrophotometric Methods for Assay and Dissolution Studies.
Martins DDFC, Florindo LC, Machado AKMDS, Todeschini V, Sangoi MDS. Martins DDFC, et al. J AOAC Int. 2017 Nov 1;100(6):1747-1753. doi: 10.5740/jaoacint.17-0013. Epub 2017 Aug 4. J AOAC Int. 2017. PMID: 28776492
This study presents the development and validation of UV spectrophotometric methods for the determination of pinaverium bromide (PB) in tablet assay and dissolution studies. The methods were satisfactorily validated according to Internati …
This study presents the development and validation of UV spectrophotometric methods for the determination of pinaverium …
Development and Validation of Discriminating and Biorelevant Dissolution Test for Lornoxicam Tablets.
Anumolu PD, Sunitha G, Bindu SH, Satheshbabu PR, Subrahmanyam CV. Anumolu PD, et al. Indian J Pharm Sci. 2015 May-Jun;77(3):312-20. doi: 10.4103/0250-474x.159653. Indian J Pharm Sci. 2015. PMID: 26180277 Free PMC article.
The objective of present work was to develop and validate a discriminating and biorelevant dissolution test for lornoxicam tablet dosage forms. To quantify the lornoxicam in dissolution samples, UV spectrophotometric method was developed using 0 …
The objective of present work was to develop and validate a discriminating and biorelevant dissolution test for lornoxi …
587 results